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Serotonin, Serotonergic Drugs, and the Serotonergic Syndrome: A Neurochemical Approach to Serotonin, Serotonergic Drugs, the Pathophysiology of Hyperserotonemia and Its Clinical Management
- Author(s):
- Toykan Dogan (see profile)
- Date:
- 2023
- Subject(s):
- Psychiatry, Psychology, Pathological, Serotoninergic mechanisms, Neurochemistry, Antidepressants, Antidepressants--Pharmacokinetics
- Item Type:
- Review
- Tag(s):
- psychiatry, serotonin, serotonergic syndrome, neurochemistry
- Permanent URL:
- https://doi.org/10.17613/6ew0-bm84
- Abstract:
- This review article summarizes the serotonin system, consisting of the neurotransmitter serotonin (5-HT), its receptors, and transporters, is a crucial component of the central nervous system; as well as the serotonergic drugs, including selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs), are commonly used in the treatment of psychiatric disorders. However, the modulation of the serotonin system through these medications can also lead to the development of a potentially life-threatening condition known as serotonergic syndrome. The serotonergic syndrome arises from an excess of serotonin activity in the brain, resulting in a constellation of symptoms such as agitation, hyperthermia, tremors, and altered mental status. This comprehensive article provides an in-depth exploration of the serotonin system, the mechanisms of action of serotonergic drugs, and the underlying neurochemical processes associated with the serotonergic syndrome. Understanding the intricate interplay between the serotonin system, serotonergic drugs, and the serotonergic syndrome is crucial for optimizing the therapeutic use of these medications while minimizing the risk of adverse effects.
- Metadata:
- xml
- Status:
- Published
- Last Updated:
- 4 months ago
- License:
- All Rights Reserved
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serotonin-dogan2023.pdf