• Effects of 6-Gingerol (6-GIN) and Delphidins (DELs) on the liver of Alloxan (ALX)-induced diabetes in Albino Wistar rats

    Author(s):
    Joseph Ikhenoba (see profile)
    Date:
    2023
    Subject(s):
    Diabetes, Medicine, Nursing, Biochemistry
    Item Type:
    Article
    Permanent URL:
    https://doi.org/10.17613/nmsq-m321
    Abstract:
    The current investigation's objective is to assess the impact of 6-Gingerol (6-GIN) and Delphidins (DELs) on the liver of an Alloxan (ALX) induced diabetic albino wistar rats. 6-Gingerol (6-GIN) and Delphidins (DELs) juice (60 mg/kg body weight) were administered daily to an Alloxan (ALX) induced diabetic rats for 60 days. 6-Gingerol (6-GIN) and Delphidins (DELs) in ALX induced diabetic rats, treatment resulted in a significant (P < 0.05).There was reduction in the levels of hepatic markers, lipid peroxidation markers like lipid hydro-peroxides (LOOH) and thiobarbituric acid reactive substances (TBARS), pro-inflammatory mediators like tumor necrosis factor-alpha (TNF-α), phosphorylated nuclear factor kappa-B-p65 (phospho-NF-B-p65) and cyclooxy. There was considerable (P < 0.05) rise in the enzymes hexokinase, glucose-6-phosphate dehydrogenase, catalase, and other enzymatic antioxidants (CAT) and the livers of diabetic rats receiving 6-GIN + DELs treatment were shown to have increase in glutathione (GSH), glutathione peroxidase (GPx), non-enzymatic antioxidants such vitamins A, D, E and K, glutathione (GSH), and anti-apoptotic protein Bcl-x, Bcl-2. Therefore, it may be inferred that the administration of ACNs + 6-GIN significantly protected the liver from the antioxidant imbalance, inflammation, and apoptosis caused by hyperglycemia and corrected the imbalance in carbohydrate metabolizing enzymes. Keywords: Alloxan; Delphidins; Gingerol; Teplizumab; inflammation; peroxidation.
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    Published
    Last Updated:
    11 months ago
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